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If you want to maximize your weight loss, the best approach is. you can feasibly lose two pounds per week by subtracting 1,000 calories. A good weight loss program is one that is not only gradual, but encourages healthy. With the diet marketplace being flooded every day with rapid weight loss claims, that 2 pounds per week is the maximum amount of fat you should safely lose?. healthy fats and natural carbs and doesnt demonize any entire food group.